Conférence Yoshio TAKEI, Professor University of Tokyo PDF Imprimer Envoyer
Mardi, 21 Janvier 2014 10:58
Conférence Yoshio TAKEI, Professor University of Tokyo

How comparative fish studies can contribute to medicine ?

Atmosphere and Ocean Research Institute,
The University of Tokyo Chair,
Department of Marine Bioscience, Head,
Division of Marine Life Science

Jeudi 23 janvier 2014

Amphi 3 - Faculté de Médecine, 22 av. Camille Desmoulins - Brest

How comparative fish studies can contribute to medicine?


I graduated from zoology but the first job after Ph.D. was in medical school where I worked for more than 10 years continuing on fish studies. The primary reason is to advertise the joy of comparative studies, but I also believed the merit of comparative studies to medicine. In this presentation, I would like to emphasize this aspect of fish endocrinological studies.

   The major differences between fish and human is blood pressure regulation. As humans must circulate blood throughout the body against gravitational force, high blood pressure is maintained by full functioning of the heart. By contrast, gravity is almost nullified by buoyancy in aquatic fish, so that their blood pressure is generally low (ca. 20 mmHg). We found that hypotensive hormones are much diversified in the fish genome database and they played major role not only blood pressure regulation but also body fluid regulation. We also identified the orthologs of fish hormones in mammals. Such hormones play minor roles in maintenance of high blood pressure in mammals and thus not discovered thus far. However, they become important in diseases such as hypertension and cardiac failure. This is the only one example of how fish studies merit medicine.

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